SiO₂-Based Aerogels Modified by Covalently Bonded Aromatic Acids as Potential Drug Delivery Systems

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Published: Aug 11, 2018
DOI: https://doi.org/10.18097/BMCRM00037
Keywords:
aerogels supercritical drying surface modification

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S.A. Lermontov
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
N.A. Sipyagina
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
A.N. Malkova
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
A.E. Baranchikov
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, 31 Leninsky av., Moscow, 119991 Russia
V.K. Ivanov
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, 31 Leninsky av., Moscow, 119991 Russia
Kh.E. Yorov
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, 31 Leninsky av., Moscow, 119991 Russia

Abstract

Hybrid aerogels (AGs) containing NH2-group were acylated by benzoic and salicylic acids. The acylated AGs had the specific area value of 170-220m2/g and were not deacylated in H2O-iPrOH mixture at 37°С during 24h. In 0.5% HCl at 37°С hydrolysis takes place releasing free acids and giving the possibility to use aminoaerogels as drug delivery system.

Article Details

How to Cite
Lermontov, S., Sipyagina, N., Malkova, A., Baranchikov, A., Ivanov, V., & Yorov, K. (2018). SiO₂-Based Aerogels Modified by Covalently Bonded Aromatic Acids as Potential Drug Delivery Systems. Biomedical Chemistry: Research and Methods, 1(3), e00037. https://doi.org/10.18097/BMCRM00037
Issue
Vol. 1 No. 3 (2018)
Section
EXPERIMENTAL RESEARCH

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