Современные тенденции в создании препаратов для лечения болезни Альцгеймера и их клинические испытания

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С.О. Бачурин
Е.В. Бовина
А.А. Устюгов

Аннотация

При болезни Альцгеймера (БА) происходит внутриклеточное и внеклеточное накопление фибриллярных белков: бета-амилоида и гиперфосфорилированного тау, которые приводят к хроническому и прогрессирующему нейродегенеративному процессу в мозге. Накопление отложений вызывает синаптическую дисфункцию и неизбежную гибель нейронов. До сих пор молекулярные механизмы БА изучены не полностью, однако установлено, что БА является многофакторным расстройством, при этом преклонный возраст является основным фактором риска. За последнее десятилетие более 50 лекарственных кандидатов успешно прошли клинические исследования II фазы, при этом ни один из них не прошел исследования фазы III. С использованием общедоступного интернет-ресурса www.clinicaltrials.gov и Alzforum.org, а также базы Thomson Reuters “Integrity” в обзоре суммированы данные по разработке препаратов для лечения болезни Альцгеймера, находящихся в настоящее время на клинических исследованиях. Выделены некоторые основные тенденции: (1) разработка соединений, действующих на основные стадии патогенеза болезни (так называемые “болезнь-модифицирующие” средства) – препараты, которые могут замедлить развитие структурных и функциональных аномалий в центральной нервной системе, обеспечивая устойчивое улучшение когнитивных функций, сохраняющихся даже после отмены препарата; (2) целенаправленная разработка мультитаргетных лекарств, действующих на несколько молекулярных мишеней, вовлеченных в патогенез болезни; (3) репозиционирование известных ранее лекарств на новое (анти-альцгеймеровское) применение, представляющее собой очень перспективный подход.

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Как цитировать
Бачурин S., Бовина E., & Устюгов A. (2018). Современные тенденции в создании препаратов для лечения болезни Альцгеймера и их клинические испытания. Biomedical Chemistry: Research and Methods, 1(3), e00015. https://doi.org/10.18097/BMCRM00015
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ОБЗОРЫ

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