Исследования комплексообразования в растворах методом ЯМР

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Опубликован: Aug 11, 2018
DOI: https://doi.org/10.18097/BMCRM00025
Ключевые слова:
ЯМР-спектроскопия комплексообразование лиганд краун-эфиры поданд циклен

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В.О. Завельский
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1
И.П. Калашникова
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1
В.П. Казаченко
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1
В.Е. Баулин
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1
О.А. Раевский
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1

Аннотация

Методами спектроскопии ЯМР исследованы процессы комплексообразования представляющих интерес для биологии и медицины органических лигандов с ионами биологически значимых металлов (Li+, Na+, Ca2+, Ga3+). Показаны возможности и преимущества методов спектроскопии ЯМР при исследовании комплексообразования. Установлена высокая чувствительность ЯМР-сигнала к образованию комплекса даже при очень малой природной концентрации магнитного изотопа. Методом ЯМР 43Ca зафиксировано образование комплекса с низкой константой устойчивости. Получены константы равновесия комплексов и параметры их ЯМР-спектров. Показана возможность применения метода ЯМР 31P и 13C для первичного тестирования комплексообразования производных циклена с катионом Ga3+ в D2O.

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Как цитировать
Завельский V., Калашникова I., Казаченко V., Баулин V., & Раевский O. (2018). Исследования комплексообразования в растворах методом ЯМР. Biomedical Chemistry: Research and Methods, 1(3), e00025. https://doi.org/10.18097/BMCRM00025
Выпуск
Том 1 № 3 (2018)
Раздел
ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ

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