Эволюция методик оценки моторной функции лабораторных грызунов, моделирующих нейродегенеративные заболевания

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Опубликован: Oct 1, 2018
DOI: https://doi.org/10.18097/BMCRM00030
Ключевые слова:
нейродегенерация походка животные модели моторная функция

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М.М. Чичёва
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1
Е.В. Вихарева
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1
А.В. Мальцев
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1
А.А. Устюгов
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1

Аннотация

В данной статье речь пойдёт о различных методиках оценки походки лабораторных грызунов. Данные методики являются репрезентативными для описания динамики нейродегенеративных заболеваний в рамках поведенческого тестирования на животных моделях. В статье перечислены такие методики как техника чернильных следов, беговые дорожки, а также современные системы TreadScan и CatWalk, позволяющие оценивать множество параметров походки животных. Для каждой из методик дано подробное описание и примеры её использования для оценки параметров походки при нейродегенеративных заболеваниях.

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Как цитировать
Чичёва M., Вихарева E., Мальцев A., & Устюгов A. (2018). Эволюция методик оценки моторной функции лабораторных грызунов, моделирующих нейродегенеративные заболевания. Biomedical Chemistry: Research and Methods, 1(3), e00030. https://doi.org/10.18097/BMCRM00030
Выпуск
Том 1 № 3 (2018)
Раздел
ОБЗОРЫ

Библиографические ссылки

  1. Arendt, T., Mosch, B., Morawski, M. (2009). Neuronal aneuploidy in health and disease: a cytomic approach to understand the molecular individuality of neurons. Int J Mol Sci, 10(4), 1609-1627. DOI
  2. Kline, R. A., Kaifer, K. A., Osman, E. Y., Carella, F., Tiberi, A., Ross, J., Pennetta, G., Lorson, C. L., Murray, L. M. (2017). Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases. PLoS Genet, 13(3), e1006680. DOI
  3. Gonzalez-Gomez, I., Mononen, I., Heisterkamp, N., Groffen, J., Kaartinen, V. (1998). Progressive neurodegeneration in aspartylglycosaminuria mice. Am J Pathol, 153(4), 1293-1300. DOI
  4. Messer, A., Strominger, N. L., Mazurkiewicz, J. E. (1987). Histopathology of the late-onset motor neuron degeneration (Mnd) mutant in the mouse. J Neurogenet, 4(4), 201-213.
  5. Yin, Z., Valkenburg, F., Hornix, B. E., Mantingh-Otter, I., Zhou, X., Mari, M., Reggiori, F., Van Dam, D., Eggen, B. J. L., De Deyn, P. P., Boddeke, E. (2017). Progressive Motor Deficit is Mediated by the Denervation of Neuromuscular Junctions and Axonal Degeneration in Transgenic Mice Expressing Mutant (P301S) Tau Protein. J Alzheimers Dis, 60(s1), S41-S57. DOI
  6. Shelkovnikova, T. A., Peters, O. M., Deykin, A. V., Connor-Robson, N., Robinson, H., Ustyugov, A. A., Bachurin, S. O., Ermolkevich, T. G., Goldman, I. L., Sadchikova, E. R., Kovrazhkina, E. A., Skvortsova, V. I., Ling, S. C., Da Cruz, S., Parone, P. A., Buchman, V. L., Ninkina, N. N. (2013). Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice. J Biol Chem, 288(35), 25266-25274. DOI
  7. D'Hooge, R., Hartmann, D., Manil, J., Colin, F., Gieselmann, V., De Deyn, P. P. (1999). Neuromotor alterations and cerebellar deficits in aged arylsulfatase A-deficient transgenic mice. Neurosci Lett, 273(2), 93-96.
  8. Fernagut, P. O., Diguet, E., Labattu, B., Tison, F. (2002). A simple method to measure stride length as an index of nigrostriatal dysfunction in mice. J Neurosci Methods, 113(2), 123-130.
  9. de Medinaceli, L., Freed, W. J., Wyatt, R. J. (1982). An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Experimental neurology, 77(3), 634-643.
  10. Wilson, J. M., Petrik, M. S., Moghadasian, M. H., Shaw, C. A. (2005). Examining the interaction of apo E and neurotoxicity on a murine model of ALS-PDC. Can J Physiol Pharmacol, 83(2), 131-141. DOI
  11. Takayanagi, N., Beppu, H., Mizutani, K., Tomita, Y., Nagao, S., Suzuki, S., Orand, A., Takahashi, H., Sonoda, S. (2013). Pelvic axis-based gait analysis for ataxic mice. J Neurosci Methods, 219(1), 162-168. DOI
  12. Guillot, T. S., Asress, S. A., Richardson, J. R., Glass, J. D., Miller, G. W. (2008). Treadmill gait analysis does not detect motor deficits in animal models of Parkinson's disease or amyotrophic lateral sclerosis. J Mot Behav, 40(6), 568-577. DOI
  13. Amende, I., Kale, A., McCue, S., Glazier, S., Morgan, J. P., Hampton, T. G. (2005). Gait dynamics in mouse models of Parkinson's disease and Huntington's disease. J Neuroeng Rehabil, 2, 20. DOI
  14. Vinsant, S., Mansfield, C., Jimenez-Moreno, R., Del Gaizo Moore, V., Yoshikawa, M., Hampton, T. G., Prevette, D., Caress, J., Oppenheim, R. W., Milligan, C. (2013). Characterization of early pathogenesis in the SOD1(G93A) mouse model of ALS: part II, results and discussion. Brain Behav, 3(4), 431-457. DOI
  15. Beare, J. E., Morehouse, J. R., DeVries, W. H., Enzmann, G. U., Burke, D. A., Magnuson, D. S., Whittemore, S. R. (2009). Gait analysis in normal and spinal contused mice using the TreadScan system. J Neurotrauma, 26(11), 2045-2056. DOI
  16. Vrinten, D. H. Hamers, F. F. (2003). 'CatWalk' automated quantitative gait analysis as a novel method to assess mechanical allodynia in the rat; a comparison with von Frey testing. Pain, 102(1-2), 203-209.
  17. Jakeman, L. B., Chen, Y., Lucin, K. M., McTigue, D. M. (2006). Mice lacking L1 cell adhesion molecule have deficits in locomotion and exhibit enhanced corticospinal tract sprouting following mild contusion injury to the spinal cord. Eur J Neurosci, 23(8), 1997-2011. DOI
  18. Van Meeteren, N. L., Eggers, R., Lankhorst, A. J., Gispen, W. H., Hamers, F. P. (2003). Locomotor recovery after spinal cord contusion injury in rats is improved by spontaneous exercise. J Neurotrauma, 20(10), 1029-1037. DOI
  19. Abu-Ghefreh, A. A. Masocha, W. (2010). Enhancement of antinociception by coadministration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naive mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis. BMC Musculoskelet Disord, 11, 276. DOI
  20. Ferreira-Gomes, J., Adaes, S., Castro-Lopes, J. M. (2008). Assessment of movement-evoked pain in osteoarthritis by the knee-bend and CatWalk tests: a clinically relevant study. J Pain, 9(10), 945-954. DOI
  21. Vandeputte, C., Taymans, J. M., Casteels, C., Coun, F., Ni, Y., Van Laere, K., Baekelandt, V. (2010). Automated quantitative gait analysis in animal models of movement disorders. BMC Neurosci, 11, 92. DOI
  22. Casteels, C., Vandeputte, C., Rangarajan, J. R., Dresselaers, T., Riess, O., Bormans, G., Maes, F., Himmelreich, U., Nguyen, H., Van Laere, K. (2011). Metabolic and type 1 cannabinoid receptor imaging of a transgenic rat model in the early phase of Huntington disease. Exp Neurol, 229(2), 440-449. DOI
  23. Chiang, M. C., Chen, C. M., Lee, M. R., Chen, H. W., Chen, H. M., Wu, Y. S., Hung, C. H., Kang, J. J., Chang, C. P., Chang, C., Wu, Y. R., Tsai, Y. S., Chern, Y. (2010). Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma. Hum Mol Genet, 19(20), 4043-4058. DOI
  24. Barber, S. C. Shaw, P. J. (2010). Oxidative stress in ALS: key role in motor neuron injury and therapeutic target. Free Radic Biol Med, 48(5), 629-641. DOI
  25. Gerber, Y. N., Sabourin, J. C., Rabano, M., Vivanco, M., Perrin, F. E. (2012). Early functional deficit and microglial disturbances in a mouse model of amyotrophic lateral sclerosis. PLoS One, 7(4), e36000. DOI
  26. Mead, R. J., Bennett, E. J., Kennerley, A. J., Sharp, P., Sunyach, C., Kasher, P., Berwick, J., Pettmann, B., Battaglia, G., Azzouz, M., Grierson, A., Shaw, P. J. (2011). Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS). PLoS One, 6(8), e23244. DOI
  27. Nanou, A., Higginbottom, A., Valori, C. F., Wyles, M., Ning, K., Shaw, P., Azzouz, M. (2013). Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis. Mol Ther, 21(8), 1486-1496. DOI
  28. Eleftheriadou, I., Manolaras, I., Irvine, E. E., Dieringer, M., Trabalza, A., Mazarakis, N. D. (2016). alphaCAR IGF-1 vector targeting of motor neurons ameliorates disease progression in ALS mice. Ann Clin Transl Neurol, 3(10), 752-768. DOI
  29. Lee, J. K., Shin, J. H., Hwang, S. G., Gwag, B. J., McKee, A. C., Lee, J., Kowall, N. W., Ryu, H., Lim, D. S., Choi, E. J. (2013). MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS. Proc Natl Acad Sci U S A, 110(29), 12066-12071. DOI
  30. Mead, R. J., Higginbottom, A., Allen, S. P., Kirby, J., Bennett, E., Barber, S. C., Heath, P. R., Coluccia, A., Patel, N., Gardner, I., Brancale, A., Grierson, A. J., Shaw, P. J. (2013). S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis. Free Radic Biol Med, 61, 438-452. DOI
  31. Audouard, E., Schakman, O., Rene, F., Huettl, R. E., Huber, A. B., Loeffler, J. P., Gailly, P., Clotman, F. (2012). The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions. PLoS One, 7(12), e50509. DOI
  32. Vergouts, M., Marinangeli, C., Ingelbrecht, C., Genard, G., Schakman, O., Sternotte, A., Calas, A. G., Hermans, E. (2015). Early ALS-type gait abnormalities in AMP-dependent protein kinase-deficient mice suggest a role for this metabolic sensor in early stages of the disease. Metab Brain Dis, 30(6), 1369-1377. DOI
  33. Scekic-Zahirovic, J., Oussini, H. E., Mersmann, S., Drenner, K., Wagner, M., Sun, Y., Allmeroth, K., Dieterle, S., Sinniger, J., Dirrig-Grosch, S., Rene, F., Dormann, D., Haass, C., Ludolph, A. C., Lagier-Tourenne, C., Storkebaum, E., Dupuis, L. (2017). Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis. Acta Neuropathol, 133(6), 887-906. DOI
  34. Scekic-Zahirovic, J., Sendscheid, O., El Oussini, H., Jambeau, M., Sun, Y., Mersmann, S., Wagner, M., Dieterle, S., Sinniger, J., Dirrig-Grosch, S., Drenner, K., Birling, M. C., Qiu, J., Zhou, Y., Li, H., Fu, X. D., Rouaux, C., Shelkovnikova, T., Witting, A., Ludolph, A. C., Kiefer, F., Storkebaum, E., Lagier-Tourenne, C., Dupuis, L. (2016). Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. EMBO J, 35(10), 1077-1097. DOI
  35. Chedly, J., Soares, S., Montembault, A., Von Boxberg, Y., Veron-Ravaille, M., Mouffle, C., Benassy, M.-N., Taxi, J., David, L., Nothias, F. (2017). Physical chitosan microhydrogels as scaffolds for spinal cord injury restoration and axon regeneration. Biomaterials, 138, 91-107.