Бактериоботы: бактериальные микророботы и их потенциал в диагностике и терапии рака

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Опубликован: Mar 13, 2026
DOI: https://doi.org/10.18097/BMCRM00301
Ключевые слова:
бактериальный микроробот; бактериобот; бактериальный биогибрид; противоопухолевая терапия

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Л.Н. Икрянникова
Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет), 119991 Москва, ул. Трубецкая, 8, стр. 2

Аннотация

Онкологические заболевания представляют серьезную проблему для общественного здравоохранения, унося миллионы жизней ежегодно. Современные методы лечения онкологий все еще имеют существенные ограничения, такие как побочные эффекты, ограниченная эффективность при метастазировании и рецидивах, и высокая стоимость, поэтому разработка новых подходов к онкотерапии является важной и приоритетной задачей. Бактерии можно рассматривать как универсальный и пластичный природный биоматериал, который обладает свойством самостоятельно передвигаться и проникать в труднодоступные участки человеческого тела, доставляя терапевтические агенты непосредственно к раковым клеткам. Также бактерии обладают естественной иммуногенностью, что позволяет привлечь иммунные клетки в зону опухоли и повысить эффективность иммунного ответа. Неудивительно, что фантастическая на первый взгляд идея создания бактериобота – автономного микроробота на основе живой бактерии для доставки терапевтического груза – становится все более популярной. В настоящем обзоре рассмотрены основные принципы конструирования бактериальных микророботов, способы их нацеливания на мишень и снабжения терапевтическим грузом, также затронуты вопросы безопасности бактериоботов для человека и перспективы их применения в лечении злокачественных новообразований.

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Как цитировать
Икрянникова L. (2026). Бактериоботы: бактериальные микророботы и их потенциал в диагностике и терапии рака. Biomedical Chemistry: Research and Methods, 9(1), e00301. https://doi.org/10.18097/BMCRM00301
Выпуск
Том 9 № 1 (2026): Принято в печать
Раздел
ОБЗОРЫ

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