Митохондрии как важная мишень при поиске новых препаратов для лечения болезни Альцгеймера и старческих деменций

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Опубликован: Sep 10, 2018
DOI: https://doi.org/10.18097/BMCRM00058
Ключевые слова:
нейродегенеративные заболевания митохондрии кальций пора митохондриальной проницаемости димебон

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E.Ф. Шевцова
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1
Д.В. Виноградова
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1
М.Е. Неганова
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1
П.Н. Шевцов
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1
Б.В. Леднев
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1
С.О. Бачурин
Институт физиологически активных веществ Российской академии наук, 142432, Черноголовка Московской обл., Северный проезд, 1

Аннотация

Обобщены собственные и литературные данные, обосновывающие роль митохондрий как важнейшей мишени при поиске препаратов для лечения нейродегенеративных заболеваний. Старение является основным фактором риска спорадических форм различных нейродегенеративных заболеваний, в том числе и болезни Альцгеймера (БА). Одной из наиболее аргументированных и принятых в настоящее время является свободнорадикальная митохондриальная теория старения. Именно с ней тесно связаны и митохондриальные гипотезы развития спорадических форм нейродегенеративных заболеваний и, в частности, БА. Нарушение митохондриальных функций приводит к снижению их способности регулировать гомеостаз кальция в клетке и снижению порога для индукции поры митохондриальной проницаемости (МРТ). Ингибиторы МРТ можно рассматривать как перспективный подход к терапии нейродегенеративных заболеваний, так как эти препараты могут не только проявлять свойства нейропротекторов, но и обеспечивать нормализацию синаптической активности благодаря увеличенной кальциевой ёмкости митохондрий. В обзоре представлены данные о ряде ингибиторов МРТ, включая эндогенные соединения – мелатонин, N-ацетилсеротонин, их биоизостерный аналог димебон и ряд других соединений. Использование митохондрий как основы для формирования скрининговой стратегии поиска соединений для лечения нейродегенеративных заболеваний представляет особый интерес и как тестирование их потенциальной токсичности, и как основа для создания метаболических стимуляторов и препаратов, обладающих нейропротекторным и когнитивно-стимулирующим действием.

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Как цитировать
Шевцова E., Виноградова D., Неганова M., Шевцов P., Леднев B., & Бачурин S. (2018). Митохондрии как важная мишень при поиске новых препаратов для лечения болезни Альцгеймера и старческих деменций. Biomedical Chemistry: Research and Methods, 1(3), e00058. https://doi.org/10.18097/BMCRM00058
Выпуск
Том 1 № 3 (2018)
Раздел
ОБЗОРЫ

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