Metal-Organic Framework Structures in Modern Research: Medicine, Diagnostics, Ecology

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Published: Oct 2, 2025
DOI: https://doi.org/10.18097/BMCRM00270
Keywords:
biosensors; MOC synthesis; MOC/COF hybrid structures; metal-organic frameworks; nucleic acids; bioimaging, fluorescence detection; fluorescence quencher

Main Article Content

Yu.V. Tumanov
State Research Center for Virology and Biotechnology “Vector” , Koltsovo, Novosibirsk Region, 630559 Russia
P.P. Gladyshev
State University Dubna, University Str. 19, Dubna, Moscow region, 141980 Russia
A.A. Sergeev
State Research Center for Virology and Biotechnology “Vector” , Koltsovo, Novosibirsk Region, 630559 Russia
A.V. Zaykovskaya
State Research Center for Virology and Biotechnology “Vector” , Koltsovo, Novosibirsk Region, 630559 Russia

Abstract

The review presents modern technological developments of means to indicate viruses and toxins using new nanomaterials based on frame structures. The synthesis and functionalization of metal-organic compounds of a frame structure (MOCs) and covalent organic frameworks (COF) are considered as well as the latest achievements in biomedical fields, including the delivery of drugs, nucleic acids, proteins and dyes for cancer therapy, bioimaging, antimicrobial drugs, biosensors and biocatalysis. New trends and promising areas in the development of biomedical materials based on MOC/COF are discussed. Data on the application of new biotechnological products based on simeconductor nanocrystals (quantum dots) and their composites as part of MOCs in solving the problems of modern disease diagnostics that play a strategic role in the development of nanotechnology, biotechnology and nanomedicine are presented. Issues related to the recognition of biomolecules using hybrid MOC/COF structures are discussed. The use of QD nanocomposites with other carbon-based, grapheme-based or MOC-based nanomaterials resulted in the development of new systems for bioimaging, drug delivery, optogenetics and theranostics. Undoubtedly, the rapidly accumulating data on the behavior of QD/MOC in analytical systems in vitro will increase knowledge for the advancement of QD nanotechnology in research in vivo and clinical application.

Article Details

How to Cite
Tumanov, Y., Gladyshev, P., Sergeev, A., & Zaykovskaya, A. (2025). Metal-Organic Framework Structures in Modern Research: Medicine, Diagnostics, Ecology. Biomedical Chemistry: Research and Methods, 8(3), e00270. https://doi.org/10.18097/BMCRM00270
Issue
Vol. 8 No. 3 (2025)
Section
REVIEWS

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