Металлорганические каркасные структуры в современных исследованиях: медицина, диагностика, экология

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Опубликован: Oct 2, 2025
DOI: https://doi.org/10.18097/BMCRM00270
Ключевые слова:
биосенсоры; синтез MOК; гибридные структуры МОК/СОF; металлоорганические каркасы; нуклеиновые кислоты; биовизуализация; детекция флуоресценции; гаситель флуоресценции

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Ю.В. Туманов
Государственный научный центр вирусологии и биотехнологии Вектор, 630559, Новосибирская область, Кольцово
П.П. Гладышев
Государственный университет "Дубна", 141980, г. Дубна, ул. Университетская 19, Московская область
А.А. Сергеев
Государственный научный центр вирусологии и биотехнологии Вектор, 630559, Новосибирская область, Кольцово
А.В. Зайковская
Государственный научный центр вирусологии и биотехнологии Вектор, 630559, Новосибирская область, Кольцово

Аннотация

В обзоре представлены современные технологические разработки средств индикации вирусов и токсинов с применением новых наноматериалов на основе каркасных структур. Рассмотрены синтез и функционализация металлорганических соединений рамочной структуры (МОК) и ковалентных органических каркасов (СОF), а также последние достижения в биомедицинских областях, включая доставку грузов (лекарств, нуклеиновых кислот, белков и красителей) для терапии рака, биовизуализации, противомикробных препаратов, биосенсорики и биокатализа. Обсуждены новые тенденции и перспективные направления в развитии биомедицинских материалов на основе MOК/СОF. Представлены данные по применению новых биотехнологических направлений на основе полупроводниковых нанокристаллов (квантовых точек, КТ) и их композитов в составе МОК в решении задач современной диагностики заболеваний, играющих стратегическую роль в развитии нанотехнологии, биотехнологии и наномедицины. Обсуждаются вопросы, связанные с распознавание биомолекул с использованием гибридных наноструктур МОК/СОF, биосенсоры и иммунотерапию. Использование нанокомпозитов КТ с другими наноматериалами на основе углерода, графена или МОК позволило разработать новые системы для биовизуализации, терапевтической доставки, оптогенетики и тераностики. Несомненно, быстро накапливаемые данные о поведении КТ/МОК в аналитических системах in vitro будут способствовать приумножению знаний для продвижения КТ-нанотехнологий в исследованиях in vivo и в клинику.

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Как цитировать
Туманов Y., Гладышев P., Сергеев A., & Зайковская A. (2025). Металлорганические каркасные структуры в современных исследованиях: медицина, диагностика, экология. Biomedical Chemistry: Research and Methods, 8(3), e00270. https://doi.org/10.18097/BMCRM00270
Выпуск
Том 8 № 3 (2025)
Раздел
ОБЗОРЫ

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